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    Cell. 1992 Aug 7;70(3):477-89.

    Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription.

    Inostroza JA, Mermelstein FH, Ha I, Lane WS, Reinberg D.

    Source

    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

    Abstract

    We have discovered a protein termed Dr1 that interacts with the TATA-binding protein, TBP. The association of Dr1 with TBP results in repression of both basal and activated levels of transcription. The interaction of Dr1 with TBP precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Dr1 activity is associated with a 19 kd protein. A cDNA clone encoding Dr1 was isolated. Dr1 is phosphorylated in vivo and phosphorylation of Dr1 affected its interaction with TBP. Our results suggest a regulatory role for Dr1 in repression of transcription mediated via phosphorylation.

    PMID:
    1339312
    [PubMed - indexed for MEDLINE]

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