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Biochim Biophys Acta. 1992 Jan 6;1129(2):249-50.

Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells.

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  • 1Department of Medicine, St. Michael's Hospital, Toronto, Canada.


A cDNA encoding rabbit endothelin-1 (ET-1) was isolated by plaque hybridization from a rabbit inferior vena caval endothelial cell lambda gt11 cDNA library using human ET-1 cDNA as the hybridization probe. DNA sequence analysis indicates that mature 21 amino acid rabbit ET-1 is derived from a 202 amino acid precursor, via a 39 amino acid intermediate 'big' ET-1.

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