Ann N Y Acad Sci. 1992 Nov 30;671:82-91.

Ca(2+)-transport ATPases and their regulation in muscle and brain.

Wuytack F, Raeymaekers L, De Smedt H, Eggermont JA, Missiaen L, Van Den Bosch L, De Jaegere S, Verboomen H, Plessers L, Casteels R.

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Katholieke Universiteit Leuven, Laboratorium voor Fysiologie, Belgium.

Abstract

Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.

PMID:: 1337687; [PubMed - indexed for MEDLINE]

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Calcium-Transporting ATPases

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Cited by 5 PubMed Central articles

Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b. [Biochem J. 2001]
Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b.
Franklin IK, Winz RA, Hubbard MJ. Biochem J. 2001 Aug 15; 358(Pt 1):217-24.
SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. [J Cell Biol. 2001]
SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.
Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, et al. J Cell Biol. 2001 Jun 11; 153(6):1301-14.
cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene. [Biochem J. 1996]
cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene.
Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Briké F, van de Ven WJ, Casteels R. Biochem J. 1996 Sep 1; 318 ( Pt 2):689-99.

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