Dev Psychobiol. 1992 Sep;25(6):427-39.

Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate.

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Department of Therapeutic Science, University of Wisconsin-Madison.

Abstract

Pregnant female rhesus monkeys were exposed to a 2-week period of adrenocorticotropic hormone (ACTH) to determine whether it would affect the early neuromotor development of their fetuses in a manner similar to that observed after psychological stressors. During the first month after birth, infants were tested on two occasions with a modification of the Brazelton Newborn Behavioral Assessment Scale. Infants derived from ACTH-treated pregnancies showed early impairments in motor coordination and muscle tonicity and shorter attention spans as compared to controls. In addition, on a temperament rating scale, infants from the ACTH condition were more irritable and difficult to console. These findings indicate that a delimited period of endocrine activation during pregnancy can have an adverse effect on infant neurobehavioral development, like that of prenatal stress.

PMID:: 1336466; [PubMed - indexed for MEDLINE]

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Review Maternal endocrine activation during pregnancy alters neurobehavioral state in primate infants. [Am J Occup Ther. 1998]
Review Maternal endocrine activation during pregnancy alters neurobehavioral state in primate infants.
Roughton EC, Schneider ML, Bromley LJ, Coe CL. Am J Occup Ther. 1998 Feb; 52(2):90-8.
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Cited by 3 PubMed Central articles

Challenges to maternal wellbeing during pregnancy impact temperament, attention, and neuromotor responses in the infant rhesus monkey. [Dev Psychobiol. 2010]
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The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. [Child Dev. 2010]
The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development.
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Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.
Bergman K, Sarkar P, Glover V, O'Connor TG. Biol Psychiatry. 2010 Jun 1; 67(11):1026-32. Epub 2010 Feb 25.

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