Clin Neuropharmacol. 1992 Oct;15(5):375-80.

Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease.

Astarloa R, Mena MA, Sánchez V, de la Vega L, de Yébenes JG.

Source

Service of Neurology, Jiménez Díaz Foundation, Madrid, Spain.

Abstract

In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjuvant treatment in patients with Parkinson's disease.

PMID:: 1330307; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Medical

Molecular Biology Databases

LEVODOPA - HSDB

Supplemental Content

Save items

Related citations in PubMed

The pharmacokinetic profile of the "first ever" oral dose of levodopa in de novo patients with Parkinson's disease. [Clin Neuropharmacol. 2001]
The pharmacokinetic profile of the "first ever" oral dose of levodopa in de novo patients with Parkinson's disease.
Djaldetti R, Rosmarin V, Ziv I, Melamed E. Clin Neuropharmacol. 2001 Mar-Apr; 24(2):95-8.
The effects of cisapride on plasma L-dopa levels and clinical response in Parkinson's disease. [Mov Disord. 1995]
The effects of cisapride on plasma L-dopa levels and clinical response in Parkinson's disease.
Neira WD, Sanchez V, Mena MA, de Yebenes JG. Mov Disord. 1995 Jan; 10(1):66-70.
Pharmacokinetics and pharmacodynamics of L-Dopa after acute and 6-week tolcapone administration in patients with Parkinson's disease. [Clin Neuropharmacol. 1999]
Pharmacokinetics and pharmacodynamics of L-Dopa after acute and 6-week tolcapone administration in patients with Parkinson's disease.
Napolitano A, Del Dotto P, Petrozzi L, Dell'Agnello G, Bellini G, Gambaccini G, Bonuccelli U. Clin Neuropharmacol. 1999 Jan-Feb; 22(1):24-9.
Review Current management of motor fluctuations in patients with advanced Parkinson's disease treated chronically with levodopa. [J Neural Transm Suppl. 1999]
Review Current management of motor fluctuations in patients with advanced Parkinson's disease treated chronically with levodopa.
Melamed E, Zoldan J, Galili-Mosberg R, Ziv I, Djaldetti R. J Neural Transm Suppl. 1999; 56:173-83.
Review Dietary factors in the management of Parkinson's disease. [Nutr Rev. 1994]
Review Dietary factors in the management of Parkinson's disease.
Kempster PA, Wahlqvist ML. Nutr Rev. 1994 Feb; 52(2 Pt 1):51-8.

See reviews... See all...

Cited by 2 PubMed Central articles

Bladder, bowel, and sexual dysfunction in Parkinson's disease. [Parkinsons Dis. 2011]
Bladder, bowel, and sexual dysfunction in Parkinson's disease.
Sakakibara R, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, Yamanishi T. Parkinsons Dis. 2011; 2011:924605. Epub 2011 Sep 12.
Bowel movement frequency in late-life and substantia nigra neuron density at death. [Mov Disord. 2009]
Bowel movement frequency in late-life and substantia nigra neuron density at death.
Petrovitch H, Abbott RD, Ross GW, Nelson J, Masaki KH, Tanner CM, Launer LJ, White LR. Mov Disord. 2009 Feb 15; 24(3):371-6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkin...
Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease.
Clin Neuropharmacol. 1992 Oct ;15(5):375-80.

PubMed
Evaluation of convulsive and subconvulsive shock therapies utilizing a control g...
Evaluation of convulsive and subconvulsive shock therapies utilizing a control group.
Am J Psychiatry. 1956 Apr ;112(10):795-802.

PubMed
Superior vena cava syndrome in children with malignancy: analysis of seven cases...
Superior vena cava syndrome in children with malignancy: analysis of seven cases.
Zhonghua Yi Xue Za Zhi (Taipei). 1992 Sep ;50(3):214-8.

PubMed
Arthrokinetic reflex of the knee.
Arthrokinetic reflex of the knee.
Am J Physiol. 1956 Feb ;184(2):433-7.

PubMed
Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and...
Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck.
Eur J Cancer B Oral Oncol. 1992 Jul ;28B(1):67-76.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information