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Arch Gynecol Obstet. 1992;252(1):31-5.

Detection of human papillomavirus in vulvar carcinoma. A study by in situ hybridisation.

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  • 1Department of Obstetrics and Gynecology, University of Berne, Switzerland.

Abstract

Fourty-four specimens of invasive cancers of the vulva, including 38 primary invasive squamous carcinomas, were analysed by in situ hybridisation with biotinylated HPV 6/11, 16 and 18 DNA probes. Four (9%) of the 44 carcinomas were positive for HPV DNA: three (7%) for HPV 16 DNA and one (2%) for HPV 6/11 DNA. HPV DNA was found only in squamous carcinomas. Of the 38 primary squamous carcinomas, 11% were positive (8% HPV 16, 3% HPV 6/11). The overall 5-year survival was 48.7%, 48.5% for the squamous carcinomas and 50.0% for the HPV DNA positive patients.

PMID:
1329678
[PubMed - indexed for MEDLINE]
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