FEBS Lett. 1992 Oct 5;310(3):265-8.

Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae.

Moczko M, Dietmeier K, Söllner T, Segui B, Steger HF, Neupert W, Pfanner N.

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Institut für Physiologische Chemie, Universität München, Germany.

Abstract

Mitochondrial protein import involves the recognition of preproteins by receptors and their subsequent translocation across the outer membrane. In Neurospora crassa, the two import receptors, MOM19 and MOM72, were found in a complex with the general insertion protein, GIP (formed by MOM7, MOM8, MOM30 and MOM38) and MOM22. We isolated a complex out of S. cerevisiae mitochondria consisting of MOM38/ISP42, the receptor MOM72, and five new yeast proteins, the putative equivalents of N. crassa MOM7, MOM8, MOM19, MOM22 and MOM30. A receptor complex isolated out of yeast cells transformed with N. crassa MOM19 contained the N. crassa master receptor in addition to the yeast proteins. This demonstrates that the yeast complex is functional, and provides strong evidence that we also have identified the yeast MOM19.

PMID:: 1327874; [PubMed - indexed for MEDLINE]

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The protein import receptor MOM19 of yeast mitochondria. [FEBS Lett. 1993]
The protein import receptor MOM19 of yeast mitochondria.
Moczko M, Gärtner F, Pfanner N. FEBS Lett. 1993 Jul 12; 326(1-3):251-4.
The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with preproteins. [Mol Cell Biol. 1995]
The mitochondrial receptor complex: Mom22 is essential for cell viability and directly interacts with preproteins.
Hönlinger A, Kübrich M, Moczko M, Gärtner F, Mallet L, Bussereau F, Eckerskorn C, Lottspeich F, Dietmeier K, Jacquet M. Mol Cell Biol. 1995 Jun; 15(6):3382-9.
Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. [J Biol Chem. 1994]
Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria.
Moczko M, Ehmann B, Gärtner F, Hönlinger A, Schäfer E, Pfanner N. J Biol Chem. 1994 Mar 25; 269(12):9045-51.
Review Mitochondrial import receptors for precursor proteins. [Trends Biochem Sci. 1991]
Review Mitochondrial import receptors for precursor proteins.
Pfanner N, Söllner T, Neupert W. Trends Biochem Sci. 1991 Feb; 16(2):63-7.
Review The mitochondrial import machinery for preproteins. [Crit Rev Biochem Mol Biol. 2001]
Review The mitochondrial import machinery for preproteins.
Rehling P, Wiedemann N, Pfanner N, Truscott KN. Crit Rev Biochem Mol Biol. 2001; 36(3):291-336.

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