The cloning of a family of genes that encode the m...[Science. 1992]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Science. 1992 Aug 28;257(5074):1248-51. Links

Comment in:: Peptides. 2006 Feb;27(2):257-8.

The cloning of a family of genes that encode the melanocortin receptors.

Mountjoy KG, Robbins LS, Mortrud MT, Cone RD.

Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.

Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.

PMID: 1325670 [PubMed - indexed for MEDLINE]

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.
FEBS Lett. 1992 Sep 14; 309(3):417-20.

[FEBS Lett. 1992]
Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene.
Biochem J. 1994 Apr 15; 299 ( Pt 2):367-73.

[Biochem J. 1994]
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.
Proc Natl Acad Sci U S A. 1993 Oct 1; 90(19):8856-60.

[Proc Natl Acad Sci U S A. 1993]
ReviewThe melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
Recent Prog Horm Res. 1996; 51:287-317; discussion 318.

[Recent Prog Horm Res. 1996]
ReviewCloning and functional characterization of a family of receptors for the melanotropic peptides.
Ann N Y Acad Sci. 1993 May 31; 680:342-63.

[Ann N Y Acad Sci. 1993]
» See reviews... | » See all...

Cited by 44 PubMed Central articles

Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway.
Enyeart JA, Enyeart JJ. PLoS One. 2009 Jun 30; 4(6):e6088. Epub 2009 Jun 30.

[PLoS One. 2009]
Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.
Chen M, Cai M, McPherson D, Hruby V, Harmon CM, Yang Y. Biochem Pharmacol. 2009 Jan 1; 77(1):114-24. Epub 2008 Sep 30.

[Biochem Pharmacol. 2009]
The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface.
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJ. J Clin Endocrinol Metab. 2008 Dec; 93(12):4948-54. Epub 2008 Oct 7.

[J Clin Endocrinol Metab. 2008]
» See all...

Recent Activity

Clear Turn Off Turn On

The cloning of a family of genes that encode the melanocortin receptors.The cloning of a family of genes that encode the melanocortin receptors.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

The cloning of a family of genes that encode the melanocortin receptors.

Related articles

Cited by 44 PubMed Central articles

Recent Activity