J Neuropsychiatry Clin Neurosci. 1992 Winter;4(1):3-14.

The calcium second messenger system in bipolar disorders: data supporting new research directions.

Dubovsky SL, Murphy J, Christiano J, Lee C.

Source

Department of Psychiatry, University of Colorado School of Medicine, Denver.

Abstract

Studies of aberrations in second messenger function may help to elucidate some of the multiple complex neurobiological alterations in bipolar affective disorders. The phosphatidylinositol and calcium ion (Ca2+) second messengers are of particular interest because of evidence of hyperactivity of these signaling mechanisms in both mania and bipolar depression and of their normalization by lithium and other mood-stabilizing treatments. Because the intracellular Ca2+ signal has a biphasic action, a single aberration could explain diverse clinical manifestations of the same illness, and a single action on the messenger could explain the biphasic actions of many treatments for bipolar disorders.

PMID:: 1320969; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

CALCIUM, ELEMENTAL - HSDB

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

Mood stabilizers: shared mechanisms of action at postsynaptic signal-transduction and kindling processes. [Harv Rev Psychiatry. 1996]
Mood stabilizers: shared mechanisms of action at postsynaptic signal-transduction and kindling processes.
Stoll AL, Severus WE. Harv Rev Psychiatry. 1996 Jul-Aug; 4(2):77-89.
Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium. [Brain Res Bull. 2001]
Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium.
Stewart RJ, Chen B, Dowlatshahi D, MacQueen GM, Young LT. Brain Res Bull. 2001 Jul 15; 55(5):625-9.
Abnormal signal transduction: a hypothetical model for bipolar affective disorder. [Life Sci. 1989]
Abnormal signal transduction: a hypothetical model for bipolar affective disorder.
Lachman HM, Papolos DF. Life Sci. 1989; 45(16):1413-26.
Review [Neuropatological and neurochemical abnormalities in bipolar disorder]. [Rev Bras Psiquiatr. 2004]
Review [Neuropatological and neurochemical abnormalities in bipolar disorder].
Frey BN, Fonseca MM, Machado-Vieira R, Soares JC, Kapczinski F. Rev Bras Psiquiatr. 2004 Sep; 26(3):180-8. Epub 2004 Nov 17.
Review Toward a biaxial model of "bipolar" affective disorders: spectrum phenotypes as the products of neuroelectrical and neurochemical alterations. [J Affect Disord. 2006]
Review Toward a biaxial model of "bipolar" affective disorders: spectrum phenotypes as the products of neuroelectrical and neurochemical alterations.
Askland K, Parsons M. J Affect Disord. 2006 Aug; 94(1-3):15-33. Epub 2006 May 24.

See reviews... See all...

Cited by 3 PubMed Central articles

Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study. [Behav Brain Funct. 2011]
Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study.
Johansson J, Landgren M, Fernell E, Vumma R, Åhlin A, Bjerkenstedt L, Venizelos N. Behav Brain Funct. 2011 Sep 24; 7:40. Epub 2011 Sep 24.
Review Calcitonin and bipolar disorder: a hypothesis revisited. [J Psychiatry Neurosci. 1998]
Review Calcitonin and bipolar disorder: a hypothesis revisited.
Vik A, Yatham LN. J Psychiatry Neurosci. 1998 Mar; 23(2):109-17.
Absence of stereoselectivity of some tricyclic antidepressants for the inhibition of depolarization-induced calcium uptake in rat cingulate cortex synaptosomes. [J Psychiatry Neurosci. 1994]
Absence of stereoselectivity of some tricyclic antidepressants for the inhibition of depolarization-induced calcium uptake in rat cingulate cortex synaptosomes.
Lavoie PA, Beauchamp G, Elie R. J Psychiatry Neurosci. 1994 May; 19(3):208-12.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The calcium second messenger system in bipolar disorders: data supporting new re...
The calcium second messenger system in bipolar disorders: data supporting new research directions.
J Neuropsychiatry Clin Neurosci. 1992 Winter ;4(1):3-14.

PubMed
Treatment of roundworm with piperazine citrate: antepar.
Treatment of roundworm with piperazine citrate: antepar.
Br Med J. 1954 Dec 4 ;2(4900):1332-3.

PubMed
Purification and characterization of two different thymidine-5'-triphosphosphate...
Purification and characterization of two different thymidine-5'-triphosphosphate-hydrolysing enzymes in human serum.
Biol Chem Hoppe Seyler. 1992 May ;373(5):237-47.

PubMed
Balint's syndrome (psychic paralysis of visual fixation) and its minor forms.
Balint's syndrome (psychic paralysis of visual fixation) and its minor forms.
Brain. 1954 ;77(3):373-400.

PubMed
[The role of magnesium and potassium in the reaction of fructokinase].
[The role of magnesium and potassium in the reaction of fructokinase].
Biochim Biophys Acta. 1952 Apr ;8(4):424-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: