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    Genomics. 1992 Jun;13(2):475-8.

    Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.

    Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D.

    Source

    Laboratory of Molecular Oncology, U. 119 INSERM, Marseille, France.

    Abstract

    A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.

    PMID:
    1319394
    [PubMed - indexed for MEDLINE]

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