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Biol Psychiatry. 1992 Apr 1;31(7):712-9.

Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal.

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  • 1Department of Psychiatry and Neurochemistry, University of Göteborg, Sweden.


Growth hormone (GH), blood pressure, and pulse rate responses to clonidine (100 micrograms IV) were studied three times during the first week of alcohol withdrawal in 19 alcohol-dependent patients. Fifteen healthy men were used as controls. The results suggest reduced sensitivity of the alpha-2-adrenoceptors involved in GH secretion for at least 1 week after the end of alcohol intake. In contrast, very short-lasting subsensitivity was found in the alpha-2-adrenoceptors regulating blood pressure.

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