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Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4840-4.

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

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  • 1Istituto Clinica Medica I, University of Perugia, Policlinico Monteluce, Italy.

Abstract

Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]. PML-RAR alpha is expressed as a fusion protein. We investigated the organization and expression pattern of the RAR alpha-PML gene in a series of APL patients representative of the molecular heterogeneity of the t(15;17) and found (i) two types of RAR alpha-PML mRNA junctions (RAR alpha exon 2/PML exon 4 or RAR alpha exon 2/PML exon 7) that maintain the RAR alpha and PML longest open reading frames aligned and are the result of chromosome 15 breaking at two different sites; and (ii) 10 different RAR alpha-PML fusion transcripts that differ for the assembly of their PML coding exons. A RAR alpha-PML transcript was present in most, but not all, APL patients.

PMID:
1317574
[PubMed - indexed for MEDLINE]
PMCID:
PMC49183
Free PMC Article
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