FEBS Lett. 1992 May 25;303(1):53-8.

Differential expression of two sodium channel subtypes in human brain.

Source

Department of Psychiatry, University of Alabama, Birmingham 35294.

Abstract

Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23-2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain, and that the relative ratio of the two forms can vary as much as 7-fold between different regions.

PMID:: 1317301; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Research Materials

anti-Sodium channel protein type 1 subunitalpha (SCN1A, Nav1.1) (C-Term) antibody - antibodies-online

Supplemental Content

Save items

Related citations in PubMed

Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23. [Proc Natl Acad Sci U S A. 1991]
Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.
Han JA, Lu CM, Brown GB, Rado TA. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):335-9.
Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24. [Cytogenet Cell Genet. 1994]
Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24.
Malo MS, Blanchard BJ, Andresen JM, Srivastava K, Chen XN, Li X, Jabs EW, Korenberg JR, Ingram VM. Cytogenet Cell Genet. 1994; 67(3):178-86.
Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31. [Proc Natl Acad Sci U S A. 1994]
Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31.
Malo MS, Srivastava K, Andresen JM, Chen XN, Korenberg JR, Ingram VM. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):2975-9.
Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. [Proc Natl Acad Sci U S A. 1992]
Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.
Ahmed CM, Ware DH, Lee SC, Patten CD, Ferrer-Montiel AV, Schinder AF, McPherson JD, Wagner-McPherson CB, Wasmuth JJ, Evans GA. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):8220-4.
cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units. [J Biol Chem. 1995]
cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.
Yang B, Ma T, Verkman AS. J Biol Chem. 1995 Sep 29; 270(39):22907-13.

See reviews... See all...

Cited by 4 PubMed Central articles

QUANTITATIVE RT-PCR ANALYSES OF FIVE EVOLUTIONARY CONSERVED GENES IN ALLIGATOR BRAINS DURING DEVELOPMENT. [Transl Neurosci. 2011]
QUANTITATIVE RT-PCR ANALYSES OF FIVE EVOLUTIONARY CONSERVED GENES IN ALLIGATOR BRAINS DURING DEVELOPMENT.
Wilson SM, Zhu T, Khanna R, Pritz MB. Transl Neurosci. 2011 Dec; 2(4):339-343.
A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. [Am J Hum Genet. 1999]
A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33.
Baulac S, Gourfinkel-An I, Picard F, Rosenberg-Bourgin M, Prud'homme JF, Baulac M, Brice A, LeGuern E. Am J Hum Genet. 1999 Oct; 65(4):1078-85.
Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns. [Biophys J. 1998]
Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns.
Selz KA, Mandell AJ, Shlesinger MF. Biophys J. 1998 Nov; 75(5):2332-42.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Differential expression of two sodium channel subtypes in human brain.
Differential expression of two sodium channel subtypes in human brain.
FEBS Lett. 1992 May 25 ;303(1):53-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: