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Differential expression of two sodium channel subtypes in human brain.
Department of Psychiatry, University of Alabama, Birmingham 35294.
Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23-2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain, and that the relative ratio of the two forms can vary as much as 7-fold between different regions.
PMID: 1317301 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33.
Baulac S, Gourfinkel-An I, Picard F, Rosenberg-Bourgin M, Prud'homme JF, Baulac M, Brice A, LeGuern E.
Am J Hum Genet. 1999 Oct; 65(4):1078-85.
[Am J Hum Genet. 1999]
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Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns.
Selz KA, Mandell AJ, Shlesinger MF.
Biophys J. 1998 Nov; 75(5):2332-42.
[Biophys J. 1998]
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Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism.
Prchal JT, Prchal JF, Belickova M, Chen S, Guan Y, Gartland GL, Cooper MD.
J Exp Med. 1996 Feb 1; 183(2):561-7.
[J Exp Med. 1996]