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    FEBS Lett. 1992 May 25;303(1):53-8.

    Differential expression of two sodium channel subtypes in human brain.

    Lu CM, Han J, Rado TA, Brown GB.

    Department of Psychiatry, University of Alabama, Birmingham 35294.

    Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23-2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain, and that the relative ratio of the two forms can vary as much as 7-fold between different regions.

    PMID: 1317301 [PubMed - indexed for MEDLINE]

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