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Biochem Biophys Res Commun. 1992 Apr 15;184(1):310-6.

Molecular cloning and binding properties of the human type II activin receptor.

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  • 1Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.


A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity.

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