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    Science. 1992 Apr 17;256(5055):370-3.

    Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.

    Wegner M, Cao Z, Rosenfeld MG.

    Source

    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648.

    Abstract

    Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBP beta, a member of the bZip family of transcription factors. In pituitary cells C/EBP beta was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin-dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta.

    PMID:
    1314426
    [PubMed - indexed for MEDLINE]

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