Gene. 1992 Mar 15;112(2):213-8.

The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.

Volpe F, Dyer M, Scaife JG, Darby G, Stammers DK, Delves CJ.

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Department of Molecular Sciences, Wellcome Research Laboratories, Kent, U.K.

Abstract

We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an Mr of 97,278. The predicted Fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function.

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The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appear...
The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.
Gene. 1992 Mar 15 ;112(2):213-8.

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