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Clin Infect Dis. 2003 Oct 1;37(7):929-32. Epub 2003 Sep 8.

Coronavirus 229E-related pneumonia in immunocompromised patients.

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  • 1Medical Intensive Care Unit, Cochin-Saint Vincent de Paul Hospital, University Paris V, Paris, France. frederic.pene@cch.ap-hop-paris.fr


Coronaviruses strains 229E and OC43 have been associated with various respiratory illnesses ranging from the self-resolving common cold to severe pneumonia. Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available. Here we report 2 well-documented cases of pneumonia related to coronavirus 229E, each with a different clinical presentation. Diagnosis was made on the basis of viral culture and electron microscopy findings that exhibited typical crown-like particles and through amplification of the viral genome by reverse transcriptase-polymerase chain reaction. On the basis of this report, coronaviruses should be considered as potential causative microorganisms of pneumonia in immunocompromised patients.

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