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Hum Pathol. 1992 Jan;23(1):82-5.

Multicentric development of pancreatic intraductal carcinoma through atypical papillary hyperplasia.

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  • 1Third Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan.


We report a case of multiple intraductal carcinomas of the pancreas associated with diffuse atypical papillary hyperplasia. A 67-year-old Japanese man with a complaint of epigastric pain was examined by endoscopic retrograde pancreatography, which demonstrated multiple dilated branches of the pancreatic duct in the body and tail of the pancreas. Histologic examination on the resected pancreas showed diffuse atypical papillary hyperplasia in multiple dilated ducts associated with multiple intraductal carcinomas. Histologic features are described and multicentric carcinogenesis through atypical papillary hyperplasia is discussed.

[PubMed - indexed for MEDLINE]
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