Nat Genet. 1992 Sep;2(1):56-60.

Genetic dissection of autoimmune type I diabetes in the BB rat.

Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES.

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Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

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Nat Genet 1994 Jun;7(2):215.

Abstract

The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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