J Clin Invest. 2003 Sep;112(6):821-4.

Turnover of lymphocytes and conceptual paradigms in HIV infection.

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Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.

Abstract

Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.

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J Clin Invest. 2003 Sep;112(6):956-66.

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PMCID: PMC193676

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