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J Biol Chem. 2003 Nov 28;278(48):48137-45. Epub 2003 Sep 12.

Trans-repression of beta-catenin activity by nuclear receptors.

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  • 1The Lombardi Cancer Center and the Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA.


The signaling/oncogenic activity of beta-catenin can be repressed by the activation of nuclear receptors such as the vitamin A, vitamin D, and androgen receptors. Although these receptors directly interact with beta-catenin and can sequester it away from its transcription factor partner T-cell factor, it is not known if this is the mechanism of trans-repression. Using several different promoter constructs and nuclear receptors and mammalian two-hybrid and mutation analyses we now show that interaction with the co-activator, p300, underlies the trans-repression of beta-catenin signaling by nuclear receptors and their ligands.

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