Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Rehabil. 2003 Sep;17(6):624-30.

The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache.

Author information

  • 1School of Physical Therapy and Rehabilitation, Dokuz Eylül University, Izmir, Turkey. selnur62@hotmail.com

Abstract

OBJECTIVE:

To observe the effects of moderate aerobic exercise on migraine headache, to assess exercise-related changes in blood nitric oxide (NO) levels, and to examine the impact of such changes on migraine attacks.

DESIGN:

Controlled clinical trial.

SETTING:

School of Physical Therapy and Rehabilitation.

SUBJECTS:

Forty women with general migraine attending the Neurology Department of the Faculty of Medicine Faculty of Dokuz Eylül University.

INTERVENTION:

Patients were assigned alternately into two groups: exercise group undertaking 1 hour aerobic exercise three times weekly, and a control group.

MAIN OUTCOME MEASURES:

Patients were assessed before and after treatment using three clinical scales--visual analogue scale for headache, Pain Disability Index and Quality of Life Scale--and chemiluminescence analysis for plasma nitric oxide.

RESULTS:

After the eight-week therapy period, patient complaints concerning the intensity, frequency and duration of pain had decreased significantly in both groups; however, visual analogue scale scoring showed better pain relief in the exercised group than in the controls (from 8.8 +/- 1.7 to 4.0 +/- 1.4 and from 8.5 +/- 0.8 to 7.0 +/- 0.9 respectively). Quality of life measures also revealed better migraine relief in the exercised women than in those who received medical treatment only. Blood NO rose significantly from pre- to post-therapy in the exercised group, but the change was not significant in the control group.

CONCLUSION:

The study showed that regular long-term aerobic exercise reduced migraine pain severity, frequency and duration possibly due to increased nitric oxide production.

PMID:
12971707
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk