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Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Bleharski JR,
Li H,
Meinken C,
Graeber TG,
Ochoa MT,
Yamamura M,
Burdick A,
Sarno EN,
Wagner M,
Röllinghoff M,
Rea TH,
Colonna M,
Stenger S,
Bloom BR,
Eisenberg D,
Modlin RL.
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
PMID: 12970564 [PubMed - indexed for MEDLINE]
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