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J Virol. 2003 Oct;77(19):10719-24.

Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency.

Author information

  • 1Department of Microbiology, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan. kkondo@jikei.ac.jp

Abstract

The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.

PMID:
12970461
[PubMed - indexed for MEDLINE]
PMCID:
PMC228414
Free PMC Article
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