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    J Diarrhoeal Dis Res. 1992 Dec;10(4):201-4.

    Effect of berberine on enterotoxin-induced intestinal fluid accumulation in rats.

    Khin-Maung-U, Nwe-Nwe-Wai.

    Source

    Clinical Research Division, Department of Medical Research, Rangoon, Myanmar, Burma.

    Abstract

    We have determined the effects of berberine (Berberis aristita) on intestinal fluid accumulation due to enterotoxigenic E. coli (ETEC) heat-stable (ST) toxin in suckling (24-days old) Wistar rats. Intestinal fluid accumulation occurred in suckling Wistar rats by administration of culture filtrate containing ST-producing ETEC in serial dilutions up to 1/8 dilution by oral or intragastric route. When berberine (0.1 mg) and 1/8 dilution of ST-toxin were given together by oral or intragastric injection, a significant (p < 0.01) reduction in fluid accumulation was observed. Neither treatment with berberine orally before intragastric injection of ST-toxin nor intragastric administration of berberine after ST-toxin reduced the fluid accumulation due to ST-toxin.

    PMID:
    1296936
    [PubMed - indexed for MEDLINE]

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