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J Neuroimmunol. 2003 Aug;141(1-2):74-82.

Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum.

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  • 1Department of Veterinary PathoBiology, University of Minnesota, St. Paul, MN 55108-6010, USA.

Abstract

Jejunal Peyer's patches (JPP) are innervated sites of immune induction and enteropathogen infection. We investigated the role of enteric nerves in modulating pathogen entry into porcine JPP. Presumptive norepinephrine (NE)-containing nerve fibers were localized in JPP domes and follicle-associated villi by secondary immunofluorescence histochemistry. NE or the neuronal conduction blocker saxitoxin increased intracellular internalization of pathogenic Salmonella choleraesuis and Escherichia coli O157:H7, but not nonpathogenic E. coli, into isolated JPP mucosa. NE action was prevented by the alpha-adrenergic antagonist phentolamine. Withdrawal of enteric neural activity or NE administration appears to modulate JPP interactions with pathogenic bacteria.

PMID:
12965256
[PubMed - indexed for MEDLINE]
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