Arch Med Res. 2003 Jul-Aug;34(4):247-68.

Gene therapy: theoretical and bioethical concepts.

Source

School of Contemporary Sciences, University of Abertay Dundee, Dundee, Scotland, UK. mltkrs@tay.ac.uk

Abstract

Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide range of disorders, including inherited conditions, cancers, and infectious diseases. Early progress has already been made in the treatment of a range of disorders. Ethical issues surrounding somatic gene therapy are primarily those concerned with safety. Germline gene therapy is theoretically possible but raises serious ethical concerns concerning future generations.

PMID:: 12957520; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Genes and Gene Therapy - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Novel vectors for in vivo gene delivery to vascular tissue. [Expert Opin Biol Ther. 2007]
Review Novel vectors for in vivo gene delivery to vascular tissue.
White K, Nicklin SA, Baker AH. Expert Opin Biol Ther. 2007 Jun; 7(6):809-21.
Review Gene therapy: progress and challenges. [Cell Mol Biol (Noisy-le-grand)...]
Review Gene therapy: progress and challenges.
Meyer F, Finer M. Cell Mol Biol (Noisy-le-grand). 2001 Dec; 47(8):1277-94.
Review Optimizing gene delivery vectors for the treatment of heart disease. [Expert Opin Biol Ther. 2008]
Review Optimizing gene delivery vectors for the treatment of heart disease.
Gray SJ, Samulski RJ. Expert Opin Biol Ther. 2008 Jul; 8(7):911-22.
Review Infection control for gene therapy: a busy physician's primer. [Clin Infect Dis. 2002]
Review Infection control for gene therapy: a busy physician's primer.
Evans ME, Lesnaw JA. Clin Infect Dis. 2002 Sep 1; 35(5):597-605. Epub 2002 Aug 7.
Review Gene therapy: principles and applications to hematopoietic cells. [Leukemia. 2001]
Review Gene therapy: principles and applications to hematopoietic cells.
Van Tendeloo VF, Van Broeckhoven C, Berneman ZN. Leukemia. 2001 Apr; 15(4):523-44.

See reviews... See all...

Cited by 3 PubMed Central articles

Nanomedicine: techniques, potentials, and ethical implications. [J Biomed Biotechnol. 2006]
Nanomedicine: techniques, potentials, and ethical implications.
Ebbesen M, Jensen TG. J Biomed Biotechnol. 2006; 2006(5):51516.
Neutrophils interact with adenovirus vectors via Fc receptors and complement receptor 1. [J Virol. 2005]
Neutrophils interact with adenovirus vectors via Fc receptors and complement receptor 1.
Cotter MJ, Zaiss AK, Muruve DA. J Virol. 2005 Dec; 79(23):14622-31.
Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline. [Int J Med Sci. 2004]
Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline.
Smith KR. Int J Med Sci. 2004; 1(2):76-91. Epub 2004 Jun 1.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gene therapy: theoretical and bioethical concepts.
Gene therapy: theoretical and bioethical concepts.
Arch Med Res. 2003 Jul-Aug ;34(4):247-68.

PubMed
Integrated family and cognitive-behavioral therapy for adolescent substance abus...
Integrated family and cognitive-behavioral therapy for adolescent substance abusers: a stage I efficacy study.
Drug Alcohol Depend. 2003 Sep 10 ;71(3):303-17.

PubMed
Understanding US addiction physicians' low rate of naltrexone prescription.
Understanding US addiction physicians' low rate of naltrexone prescription.
Drug Alcohol Depend. 2003 Sep 10 ;71(3):219-28.

PubMed
Nonrandomized comparison between definitive chemoradiotherapy and radical surger...
Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T(2-3)N(any) M(0) squamous cell carcinoma of the esophagus.
Int J Radiat Oncol Biol Phys. 2003 Oct 1 ;57(2):425-33.

PubMed
A comparative study of the anticholinesterase activity of several antipsychotic ...
A comparative study of the anticholinesterase activity of several antipsychotic agents.
Pharmacol Biochem Behav. 2003 Jul ;75(4):895-901.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: