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Chang Gung Med J. 2003 Jun;26(6):388-402.

Mechanisms and clinical relevance of androgens and androgen receptor actions.

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  • 1Graduate Institute of Clinical Medical Sciences, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Abstract

Androgens, principally testosterone and 5alpha-dihydrotestosterone, affect a number of diverse responses in a variety of peripheral target tissues. Their biological actions are mediated by a ligand-dependent nuclear transcription factor, the androgen receptor (AR). The AR is a member of the steroid hormone receptor family, which is found in a variety of tissues, and changes throughout development, aging, and malignant transformation. Recently, cloning and characterization of several AR co-regulators have allowed for cellular and molecular analysis of many different aspects of androgen physiology and pathophysiology. The transcriptional activity of AR is regulated by AR co-regulators, which influence the ligand selectivity and DNA binding capacity of AR. Aberrant co-regulator function due to mutation or altered expression levels may be a contributing factor in the progression of AR-mediated diseases. However, in spite of the intensity of research activity in this area, many interesting questions regarding the fundamental mechanism of AR and co-regulators on androgen-related diseases, such as osteoporosis and androgen insensitive syndrome remain unsolved. In this review, we provide a brief overview of genomic and non-genomic androgens/AR actions, as well as the regulation of their co-regulators. We also explore several intriguing aspects of the molecular biology of AR and co-regulators that are related to clinical diseases.

PMID:
12956285
[PubMed - indexed for MEDLINE]
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