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1: Nephrol Dial Transplant. 2003 Aug;18 Suppl 6:vi26-9.Click here to read Links

Immune dysregulation in minimal change nephropathy.

Mathieson PW.

Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK. p.mathieson@bris.ac.uk

Minimal change nephropathy (MCN) has been associated with a wide variety of abnormalities in the immune response of affected individuals. Many of these may be a consequence of the renal lesion, rather than a cause thereof. This article reviews some of these immunological phenomena and concentrates in particular on the imbalance between type 1 and type 2 cytokine responses, suggesting that there are plausible mechanisms whereby a type 2 cytokine bias could directly or indirectly cause MCN.

PMID: 12953038 [PubMed - indexed for MEDLINE]