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J Lipid Res. 2003 Nov;44(11):2019-29. Epub 2003 Sep 1.

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease.

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  • 1Research and Development, Veterans Affairs Chicago Health Care System-West Side VA Medical Center, and Department of NeuroAnesthesiology, University of Illinois at Chicago, Chicago, IL 60612, USA. nchauhan@uic.edu

Abstract

Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid (A beta) plaques derived from the amyloidogenic processing; of a transmembrane protein called beta-amyloid precursor protein (APP). In addition to the known genetic/sporadic factors that promote the formation of A beta, the composition and structural dynamics of the membrane are also thought to play a significant role in the amyloidogenic processing of APP that promotes seeding of A beta. This minireview reinforces the roles played by membrane dynamics, membrane microdomains, and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating AD.

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