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1: Psychiatry Clin Neurosci. 2003 Oct;57(5):542-4.Click here to read Links

Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients.

Karam-Hage M, Brower KJ.

Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48108, USA.

Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose +/- SD = 888 +/- 418 mg) at bedtime and 16 were treated with trazodone (105 +/- 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.

PMID: 12950711 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Gabapentin (Gabarone® , Neurontin® )

    Gabapentin is used to help control certain types of seizures in patients who have epilepsy. Gabapentin is also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last fo...

  • Trazodone

    Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balan...

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