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Curr Opin Struct Biol. 2003 Aug;13(4):404-11.

The versatile beta-barrel membrane protein.

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  • Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA. wwimley@tulane.edu


The beta-barrel membrane protein is found in the outer membranes of bacteria, mitochondria and chloroplasts. Approximately 2-3% of the genes in Gram-negative bacterial genomes encode beta-barrels. Whereas there are fewer than 20 known three-dimensional beta-barrel structures, genomic databases currently contain thousands of beta-barrels belonging to dozens of families. New research is revealing the variety of beta-barrel structures and the variety of functions performed by these versatile proteins.

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