Med Sci (Paris). 2003 Jun-Jul;19(6-7):743-52.

[Focal adhesion kinase (FAK), a multifunctional protein].

[Article in French]

Source

Laboratoire Mort Cellulaire et Néoplasie, Faculté de médecine J. Lisfranc de Saint-Etienne, 15, rue Ambroise Paré, 42023 Saint-Etienne, France. jerome_cornillon@hotmail.com

Abstract

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase localized to regions called focal adhesions. Many stimuli can induce tyrosine phosphorylation and activation of FAK, including integrins and growth factors. The major site of autophosphorylation, tyrosine 397, is a docking site for the SH2 domains of Src family proteins. The other sites of phosphorylation are phosphorylated by Src kinases. Phosphorylated FAK binds proteins of focal adhesion and can activate them directly or indirectly by phosphorylation. These activated proteins forming the FAK complex facilitate the generation of downstream signals necessary to regulate cell functions, like motility, survival and proliferation. Dysregulation of FAK could participate in the development of cancer. This review will focus upon the mechanisms by which FAK transmits biochemical signals and elicits biological effects.

PMID:: 12942446; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. [Mol Cell Biol. 1996]
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.
Vuori K, Hirai H, Aizawa S, Ruoslahti E. Mol Cell Biol. 1996 Jun; 16(6):2606-13.
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. [Mol Cell Biol. 1996]
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
Schlaepfer DD, Hunter T. Mol Cell Biol. 1996 Oct; 16(10):5623-33.
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. [J Biol Chem. 2003]
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts.
Moissoglu K, Gelman IH. J Biol Chem. 2003 Nov 28; 278(48):47946-59. Epub 2003 Sep 18.
Review Biochemical signals and biological responses elicited by the focal adhesion kinase. [Biochim Biophys Acta. 2001]
Review Biochemical signals and biological responses elicited by the focal adhesion kinase.
Schaller MD. Biochim Biophys Acta. 2001 Jul 25; 1540(1):1-21.
Review Role of focal adhesion kinase in integrin signaling. [Int J Biochem Cell Biol. 1997]
Review Role of focal adhesion kinase in integrin signaling.
Guan JL. Int J Biochem Cell Biol. 1997 Aug-Sep; 29(8-9):1085-96.

See reviews... See all...

Cited by 1 PubMed Central article

Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma. [Int J Mol Sci. 2011]
Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma.
Fan DM, Shi HR. Int J Mol Sci. 2011; 12(12):8489-501. Epub 2011 Nov 29.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

[Focal adhesion kinase (FAK), a multifunctional protein].
[Focal adhesion kinase (FAK), a multifunctional protein].
Med Sci (Paris). 2003 Jun-Jul ;19(6-7):743-52.

PubMed
The role of family factors, physical abuse, and sexual victimization experiences...
The role of family factors, physical abuse, and sexual victimization experiences in high-risk youths' alcohol and other drug use and delinquency: a longitudinal model.
Violence Vict. 1992 Fall ;7(3):245-66.

PubMed
Micronutrients and human immunodeficiency virus type 1 disease progression among...
Micronutrients and human immunodeficiency virus type 1 disease progression among adults and children.
Clin Infect Dis. 2003 ;37 Suppl 2:S112-6.

PubMed
Sex, race, age, and violent offending.
Sex, race, age, and violent offending.
Violence Vict. 1992 Fall ;7(3):191-201.

PubMed
Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix.
Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix.
Arch Gynecol Obstet. 2004 Dec ;270(4):278-80. Epub 2003 Aug 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

[Focal adhesion kinase (FAK), a multifunctional protein].

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information