Send to:

Choose Destination
See comment in PubMed Commons below
Evolution. 2003 Jul;57(7):1489-97.

Within-host parasite dynamics, emerging trade-off, and evolution of virulence with immune system.

Author information

  • 1Laboratoire Génome, Populations, Interactions, Adaptation, UM2-IFREMER-CNRS UMR 5000, Université Montpellier II-CC 063, Bâtiment 13, RdC, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.


Virulence is an evolutionary paradox because parasites never benefit from their host's death. The adaptive explanation of virulence is classically based upon the existence of physiological constraints that create a trade-off between parasites' epidemiological traits (virulence, transmissibility, and clearance). Here we develop an epidemiological model where infections are dynamic processes and we demonstrate how these dynamics generate a trade-off between emerging epidemiological parameters. We then study how host's immune strength modifies this trade-off and hence influences virulence evolution. We found that in acute infections, where parasites are engaged in a race with immune cells, immunity restrains more the duration of the infection than its intensity. As a consequence parasites evolve to provoke more virulent but shorter infections in strongly immunized hosts.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk