Geriatrics. 2003 Aug;58(8):33-8; quiz 41.

Hypercholesterolemia. The NCEP Adult Treatment Panel III Guidelines.

Source

Jefferson Medical College, Thomas Jefferson University, Cardiovascular Disease Prevention Center, Jefferson Heart Institute, Philadelphia, USA.

Abstract

Coronary heart disease (CHD) is a significant cause of morbidity and mortality in older patients. Therefore, its treatment and prevention is vital to improving the length and quality of life for the geriatric population at large. Clinical trial data have demonstrated that patients age 65 and older derive the same benefit from blood cholesterol reduction as younger adults. As a result, the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) recommends appropriate therapeutic lifestyle changes and drug therapy for older individuals with established CHD or for those at high risk for CHD. Drug therapy in this population, while safe, requires careful monitoring and dose adjustment due to potentially altered drug metabolism and concomitant medications. These factors lead to use of lower starting doses of lipid-lowering medications in older patients. Prudent individualized evaluation and customized therapy provide optimal cardiovascular outcomes.

PMID:: 12938250; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Hypolipidemic Agents

LinkOut - more resources

Full Text Sources

EBSCO

Medical

Cholesterol - MedlinePlus Health Information

Supplemental Content

Related citations

Review Medical lipid-regulating therapy: current evidence, ongoing trials and future developments. [Drugs. 2004]
Review Medical lipid-regulating therapy: current evidence, ongoing trials and future developments.
Evans M, Roberts A, Davies S, Rees A. Drugs. 2004; 64(11):1181-96.
Impact of evidence-based "clinical judgment" on the number of American adults requiring lipid-lowering therapy based on updated NHANES III data. National Health and Nutrition Examination Survey. [Arch Intern Med. 2000]
Impact of evidence-based "clinical judgment" on the number of American adults requiring lipid-lowering therapy based on updated NHANES III data. National Health and Nutrition Examination Survey.
Jacobson TA, Griffiths GG, Varas C, Gause D, Sung JC, Ballantyne CM. Arch Intern Med. 2000 May 8; 160(9):1361-9.
Estimating the impact of adding C-reactive protein as a criterion for lipid lowering treatment in the United States. [J Gen Intern Med. 2007]
Estimating the impact of adding C-reactive protein as a criterion for lipid lowering treatment in the United States.
Woloshin S, Schwartz LM, Kerin K, Welch HG. J Gen Intern Med. 2007 Feb; 22(2):197-204.
Review Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. [J Am Coll Cardiol. 2004]
Review Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines.
Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ, Coordinating Committee of the National Cholesterol Education Program. J Am Coll Cardiol. 2004 Aug 4; 44(3):720-32.
Review Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. [Arterioscler Thromb Vasc Biol. 2004]
Review Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.
Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ, Coordinating Committee of the National Cholesterol Education Program. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):e149-61.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. [Eur J Pharmacol. 2008]
Review Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective.
Luchsinger JA. Eur J Pharmacol. 2008 May 6; 585(1):119-29. Epub 2008 Mar 4.
Review Adiposity and Alzheimer's disease. [Curr Alzheimer Res. 2007]
Review Adiposity and Alzheimer's disease.
Luchsinger JA, Mayeux R. Curr Alzheimer Res. 2007 Apr; 4(2):127-34.
Aggregation of vascular risk factors and risk of incident Alzheimer disease. [Neurology. 2005]
Aggregation of vascular risk factors and risk of incident Alzheimer disease.
Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R. Neurology. 2005 Aug 23; 65(4):545-51.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hypercholesterolemia. The NCEP Adult Treatment Panel III Guidelines.
Hypercholesterolemia. The NCEP Adult Treatment Panel III Guidelines.
Geriatrics. 2003 Aug ;58(8):33-8; quiz 41.

PubMed
Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
Endocr Rev. 2003 Dec ;24(6):719-36.

PubMed
Coffee intake and CYP1A2*1F genotype predict breast volume in young women: impli...
Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer.
Br J Cancer. 2008 Nov 4 ;99(9):1534-8. Epub 2008 Sep 23 .

PubMed
Effectiveness of telemedicine in replacing in-person evaluation for acute childh...
Effectiveness of telemedicine in replacing in-person evaluation for acute childhood illness in office settings.
Telemed J E Health. 2006 Jun ;12(3):308-16.

PubMed
The history of epidemic typhus.
The history of epidemic typhus.
Infect Dis Clin North Am. 2004 Mar ;18(1):127-40.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: