Abstract
The neurotoxic lipopeptide (+)-kalkitoxin was synthesized by a route which employed asymmetric organocopper conjugate addition followed by in situ enolate alkylation to install the anti,anti-1,2,4-trimethyl relationship of the toxin; the synthesis of kalkitoxin required sixteen steps and proceeded in 3% overall yield.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Crystallography, X-Ray
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Lipids / chemical synthesis*
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Lipids / chemistry
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Lipoproteins / chemical synthesis
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Lipoproteins / chemistry
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Models, Chemical
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Neurotoxins / chemical synthesis
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Neurotoxins / chemistry
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Stereoisomerism
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
Substances
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Lipids
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Lipoproteins
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Neurotoxins
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Thiazoles
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kalkitoxin