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Neuroscientist. 2003 Aug;9(4):237-42.

Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing.

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  • 1Department of Psychiatry and Neuroscience, Columbia University College of Physicians & Surgeons, New York State Psychiatric Institute, USA. schmauss@neuron.cpmc.columbia.edu

Erratum in

  • Neuroscientist. 2003 Oct;9(5):419.

Abstract

Transcripts of the gene encoding the serotonin 2C receptor are modified by RNA editing, a posttranscriptional process that converts adenosines to inosines. This editing changes up to three genomically encoded amino acids located in the second intracellular loop of the G-protein-coupled receptor. Compared with nonedited receptors, extensively edited receptor isoforms activate G protein less efficiently. Studies on mice revealed that 5-HT2C pre-mRNA editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-HT2C mRNA isoforms. At present, the most complex alterations in 5-HT2C pre-mRNA editing were found in brains of depressed suicide victims. In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective.

PMID:
12934707
[PubMed - indexed for MEDLINE]
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