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Science. 2003 Aug 22;301(5636):1099-102.

Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation.

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  • 1Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, LMU München, Germany.

Abstract

Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells. We found that VacA could efficiently block proliferation of T cells by inducing a G1/S cell cycle arrest. It interfered with the T cell receptor/interleukin-2 (IL-2) signaling pathway at the level of the Ca2+-calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of immune response genes, was abrogated, resulting in down-regulation of IL-2 transcription. VacA partially mimicked the activity of the immunosuppressive drug FK506 by possibly inducing a local immune suppression, explaining the extraordinary chronicity of Hp infections.

PMID:
12934009
[PubMed - indexed for MEDLINE]
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