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J Clin Invest. 2003 Aug;112(4):460-7.

The enigma of sepsis.

Author information

  • 1Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109-0602, USA.

Abstract

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.

PMID:
12925683
[PubMed - indexed for MEDLINE]
PMCID:
PMC171398
Free PMC Article

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