Arch Neurol. 2003 Aug;60(8):1045-9.

The hereditary spastic paraplegias: nine genes and counting.

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Department of Neurology, University of Michigan, 5214 Cancer Geriatrics Center Bldg., Box 0940, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. jkfink@umich.edu

Abstract

The hereditary spastic paraplegias (HSPs) are inherited neurologic disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity weakness and spasticity. There have been great strides in our knowledge of this group of disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the molecular causes of HSPs are beginning to emerge. This review summarizes these advances in HSPs' genetics.

Comment in

Allan-Herndon-Dudley syndrome: should the locus for this hereditary spastic paraplegia be designated SPG 22? [Arch Neurol. 2004]
Allan-Herndon-Dudley syndrome: should the locus for this hereditary spastic paraplegia be designated SPG 22?Bohan TP, Azizi P. Arch Neurol. 2004 Sep; 61(9):1470-1; author reply 1471.

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Review Advances in the hereditary spastic paraplegias. [Exp Neurol. 2003]
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