Nat Genet. 2003 Aug;34(4):369-76.

Chromosome aberrations in solid tumors.

Albertson DG, Collins C, McCormick F, Gray JW.

Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA. albertson@cc.ucsf.edu

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

PMID: 12923544 [PubMed - indexed for MEDLINE]

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