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Dev Cell. 2003 Aug;5(2):187-8.

The quest for the holy "G" of chromosomal passengers.

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  • 1Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA.


Twelve years after reporting a novel chromosomal passenger protein, Mollinari et al. in this issue of Developmental Cell finally report its molecular identification, and the results are stunning. TD-60 is a member of the RCC1 family of guanine nucleotide exchange factors implicating small GTPases in chromosome congression and cytokinesis.

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