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Leuk Lymphoma. 2003 Jul;44(7):1243-5.

Primary CD30/Ki-1 positive anaplastic large cell lymphoma of the central nervous system occurring in a patient with a seventeen-year history of essential thrombocythemia.

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  • 1Department of Neurology, Sapporo City General Hospital, N 11, W13, Chu-o-ku, Sapporo, 060-8604, Japan.


We present a rare case of central nervous system lymphoma that occurred in a patient who had essential thrombocythemia for 17 years. MRI examinations disclosed multiple ring-enhanced lesions that had shown bilateral spreading in the different period. Pathological examinations confirmed CD30/Ki-1-positive ALK negative anaplastic large cell lymphoma. The possible pathogenic mechanisms of this disease are discussed.

[PubMed - indexed for MEDLINE]
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