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J Hypertens Suppl. 1992 Dec;10(7):S39-44.

The fetal origins of adult hypertension.

Author information

  • MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.

Abstract

AIM:

To elucidate the fetal origins of hypertension.

METHODS:

A systematic search was made for records of early growth, comprising measurements taken either at birth and/or during infancy, for groups of men and women now in middle-late life. Over 25,000 men and women born before 1931 were successfully traced.

RESULTS:

Retarded growth in fetal life was strongly related to high blood pressure in adult life.

CONCLUSION:

Hypertension is programmed by an adverse environment in utero. It is linked to impaired development in both early and late gestation.

PMID:
1291655
[PubMed - indexed for MEDLINE]
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