Comparative genomics of Archaea: how much have we ...[Genome Biol. 2003]

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1: Genome Biol. 2003;4(8):115. Epub 2003 Jul 16. Links

Comparative genomics of Archaea: how much have we learned in six years, and what's next?

Makarova KS, Koonin EV.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. koonin@ncbi.nlm.nih.gov

Archaea comprise one of the three distinct domains of life (with bacteria and eukaryotes). With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' that is prone to lineage-specific gene loss and horizontal gene exchange. The majority of archaeal genes have not been experimentally characterized, but novel functional pathways have been predicted.

PMID: 12914651 [PubMed - indexed for MEDLINE]

PMCID: PMC193635

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