Your browser version may not work well with NCBI's Web applications. More information here...
1: Int J Gynecol Cancer. 2003 Jul-Aug;13(4):515-7.Click here to read Links

Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality.

Sindos M, Ndisang D, Pisal N, Chow C, Deery A, Singer A, Latchman D.

Institute of Child Health, University College London, UK. sindosgyn@hotmail.com

Measurement of the Brn-3a cellular transcription factor in cervical smears from women referred for colposcopy may improve the detection of underlying cervical neoplasia. In those women referred with persisting borderline or mildly dyskaryotic smears, those who had histologically proven underlying CIN II/III, had statistically significant higher Brn-3a levels than those with a similar smear but histologically shown to have HPV, CIN I, or no cervical abnormality. These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.

PMID: 12911730 [PubMed - indexed for MEDLINE]