The effect of normobaric hyperoxia on cardiac index in healthy awake volunteers

Anaesthesia. 2003 Sep;58(9):885-8. doi: 10.1046/j.1365-2044.2003.03333.x.

Abstract

Fifteen healthy volunteers were exposed to a stepwise increase in FIO2 between 0.21 and 1.0, and their haemodynamic responses were measured with a non-invasive transthoracic bio-impedance monitor. There was mean reduction in cardiac index from 3.44 to 3.08 l.min-1.m-2 (10.7%, p < 0.001). The mean reduction in heart rate was from 77.3 to 69.1 beats.min-1 (10.5%, p < 0.001) and the mean systemic vascular index increased from 2062 to 2221 dyne.s-1.cm-5.m-2 (7.7%, p < 0.025). There were no significant changes in stroke index or mean arterial pressure. These changes are similar quantitatively and qualitatively to those previously reported by dye dilution techniques.

MeSH terms

  • Adult
  • Cardiac Output / drug effects*
  • Cardiography, Impedance
  • Female
  • Hemodynamics / drug effects
  • Humans
  • Male
  • Middle Aged
  • Oxygen / blood
  • Oxygen / pharmacology*
  • Partial Pressure

Substances

  • Oxygen