Growth Regul. 1992 Dec;2(4):151-5.

Role of platelet derived growth factor in bone cell function.

Canalis E, Varghese S, McCarthy TL, Centrella M.

Source

Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105.

Abstract

PDGF is a mitogen for cells of the osteoblastic lineage. PDGF is present in the systemic circulation and is locally synthesized by skeletal cells. The systemic form primarily contains PDGF B chains, which are intrinsically more active than PDGF A subunits, the forms secreted by normal bone cells. PDGF AA is regulated by other growth factors and cytokines, which modulate its binding to osteoblastic receptors and its synthesis by skeletal cells. The exact role of PDGF in bone remodelling is still uncertain and current information suggests that this factor has a function in the response to inflammation and wound healing.

PMID:: 1290951; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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Platelet-Derived Growth Factor

Grant Support

AR 21707/AR/NIAMS NIH HHS/United States

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