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Trends Immunol. 2003 Aug;24(8):456-64.

Hepatitis C virus infection: when silence is deception.

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  • 1Liver Diseases Section, NIDDK, National Institutes of Health, 10 Center Drive, Room 9B16, Bethesda, MD 20892, USA.


Hepatitis C virus (HCV) uses complex and unique mechanisms to prevent, evade or subvert innate and adaptive immune responses and to establish persistent infection and chronic hepatitis. Recently developed experimental systems have significantly facilitated the analysis of HCV replication, virus-host interaction and pathogenesis of chronic hepatitis and have provided new insights into the mechanisms of HCV clearance and persistence.

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