Brain Res Bull. 2003 Aug 15;61(3):281-5.

Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern.

Petzold A, Keir G, Lim D, Smith M, Thompson EJ.

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Department of Neuroimmunology of the Institute of Neurology, Queen Square, WC1N 3BG London, UK.

Abstract

S100B is an important brain specific protein for monitoring damage and activation of astrocytes. Using a straight forward, non-resource demanding in-house ELISA technique we measured S100B in cerebrospinal fluid (CSF) and serum in patients with traumatic brain injury (TBI) (serum), subarachnoid hemorrhage (SAH) (CSF, serum), intracranial hemorrhage (ICH) (CSF, serum), normal controls (NC) (serum) and a reference population (CSF, N=409). The release and wash-out pattern found in CSF and serum are discussed in relation to the three main determinants for increased brain specific protein levels in body fluids: (i) total mass effect; (ii) pathology; and (iii) time effect.

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